Causes

• Liver diseases
  • Cholestasis Pattern (all 3)
• Liver infiltration
  • Amyloidosis
  • Malignancy
• Pregnancy - Placenta
• Also a non-specific marker of excessive bone formation, non-specific
  • <20 - High bone turn-over due to growth
  • elevated - secondary osteoporosis (e.g. Paget’s Disease)