At least 2 of the following signs or symptoms, developing during, or shortly after, stimulant use:

1. Tachycardia or bradycardia
2. Pupillary dilation
3. Elevated or lowered blood pressure
4. Perspiration or chills
5. Nausea or vomiting
6. Evidence of weight loss
7. Psychomotor agitation or retardation
8. Muscular weakness, respiratory depression, chest pain, or cardiac arrhythmias
9. Confusion, seizures, dyskinesias (i.e. - involuntary, erratic, writhing “dance-like” movements of the face, arms, legs or trunk), dystonias (i.e. - slow repetitive movements or abnormal posture), or coma

Signs and Symptoms

• Amphetamine intoxication: euphoria, grandiosity, pupillary dilation, prolonged wakefulness, hyperalertness, hypertension, paranoia, fever, fractured teeth, skin excoriations (in methamphetamine use)
  • Paranoia is a more characteristic feature of amphetamine intoxication (than cocaine).
  • Severe events can include cardiac arrest, seizures, and death.
• Cocaine intoxication: impaired judgment, pupillary dilation, hallucinations (including tactile), paranoia, angina, sudden cardiac death.
  • Chronic use may lead to perforated nasal septum due to vasoconstriction and resulting ischemic necrosis.