Conditions:

• Smoking (RF) cessation
• MDD (5/9, 2 wk)

CI: !Seizure , ****Hx of Eating Disorder , MAOi (A/B) in 14 days (hypotensive crisis)

MOA:

Administration:

• Oral medication that is increased in dose over a week, with smoking cessation after the first week of therapy

Side effects:

• Stimulation, agitation, weight loss, seizure, tachycardia
• Avoid alcohol (seizure)

| Atypical agents | Anticholinergic | Drowsiness | Insomnia/ agitation | Orthostatic hypotension | QTc prolongation* | Gastrointestinal toxicity | Weight gain | Sexual dysfunction | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | Agomelatine§ (not available in United States) | 0 | 1+ | 1+ | 0 | 0 | 1+ | 0 | 0 to 1+ | | Bupropion (Wellbutrin®) | 0 | 0 | 2+ | 0 | 0 to 1+¥ | 1+ | 0 | 0 | | Dextromethorphan-bupropion | 0 | 1+ | 1+ | 0 | 0 to 1+¥ | 1+ | 0 | 1+ | | ‣ | 1+ | 4+ | 0 | 0 | 1+ | 0 | 4+ | 1+ |

• Foot Note

Pro:

• VS SSRI/SNRI : No sexual side-effect

Con:

• Jittering -> people with anxiety might not tolerate it