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Subitems

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Examples:

Primary goal	Interrupt cell growth/metabolism
Typical Uses	Cancer, autoimmune, transplant
Common examples	Methotrexate, Azathioprine
Mechanism	Metabolic pathway inhibition

Definition:

Drugs that interfere with the synthesis of nucleic acids (DNA/RNA) by mimicking and substituting normal metabolites necessary for cell growth, division, or function.

Mechanism:

Competitive inhibition or false incorporation into DNA/RNA synthesis pathways.
Leads to disruption of normal cell division and proliferation, particularly in rapidly dividing cells (e.g., immune cells or cancer cells).

Clinical Uses:

Chemotherapy for cancer
Immunosuppressants in autoimmune disorders (rheumatoid arthritis, lupus)
Prevention of transplant rejection