eGPA – Eosinophilic Granulomatosis with Polyangiitis

• Vessels involved: Small–medium vessels.
• Pathology: Granulomatous + eosinophil-rich inflammation.
• Organs:
  • Asthma + allergic rhinitis + nasal polyps (prodromal).
  • Eosinophilia in blood/tissue.
  • Lungs: transient pulmonary infiltrates.
  • Heart: myocarditis, pericarditis (major morbidity).
  • Nerves: mononeuritis multiplex.
• ANCA: MPO-ANCA (p-ANCA) in ~40%, but not all are ANCA-positive.
• Buzzwords: Asthma, eosinophilia, vasculitis.