Examples:

• long acting: Chlorthalidone, Indapamide
• short acting: HCTZ - Hydrochlorothiazide

Effect: 5-10% reduction in Na reabsorption → decreased BV → decreased BP

• initial: diuretic
• long term: vasodilation

Conditions:

• ↑High BP → long acting preferred

CI: !anuria

MOA: block Na reuptake at DCT

Side effects:

• Hypotension ↓(<90/60)
• Hyponatremia ↓ [Na] (<135) (highest risk on all diuretics)
• Hypokalemia - ↓K (<3.5)
• Hyperuricemia ↑ (uric acid → goat)