Examples:

• Desmopressin (DDAVP), Vasopressin (AVP)

Effect:

• Similar to that of ADH
• Increase water in the body (decrease [Na])
  • Decrease urine volume
  • Increase urine osmolarity

Conditions:

• When there is too little water in the body
  • DI - Diabetes Insipidus
  • Hypernatremia ↑ Na (> 145)

CI:

• ESRF (< 15)

Side effects:

• Ischemia
  • !CLI - Critical Limb Ischemia (6Ps, 6h)
  • Mesenteric ischemia
  • Skin ischemia
• Hyponatremia ↓ [Na] (<135)

MOA:

• Act as ADH

Admin:

• Not parental (Not PO)
• Sublingual, IV