• A sensitive but not specific test for SLE - Lupus
  • Sensitivity: 95-100%
  • Not specific
    • Normally high
      • Female, Older Adult > 65 (RF)
    • Other SARD
    • Other chronic inflammatory diseases
      • Hepatitis
      • Autoimmune Liver Disease
      • Autoimmune Thyroid Diseases
    • Chronic infections, e.g., Mycobacterium tuberculosis , SBE, Infectious mononucleosis
    • Drug
      • NaC Blocker (Heart) → Procainamide
      • TNF-a inhibitor
• ENA are specific ANAs
  • If ANA is positive, you then order specific subsequent tests to detect specific ENAs