• 15% Germ-Line
• 20% Somatic

BRCA1

• 60 - 80% risk of BC
• Risk is that high for BOTH breast independent
• Public: 1/8 or 1/9
• Highest in Africa
• Ovarian Ca earlier (35-40 yo)

BRCA2

• 40% risk of BC
• Ovarian Ca later (40 - 45 yo)