Vaughan Williams Class: IV

Calcium Channel Blocker

Examples + effects

DHP-CCB (”ipine”) → Vasculature (vasodilation)

Amlodipine → Has combination pill with Perindopril (coversyl®)

Nifedipine

Non-DHP CCB →Cardiac (negative inotrope) + Vasculature (vasodilation)

Diltiazem

• Verapamil

Dopamine Antagonist → Anti-emetic

• flunarizine
• Cinnarizine

Condition

• ↑High BP (esp. DHP-CCB (”ipine”) )
• Stable Angina
• !Arrhythmia (esp. Non-DHP CCB )
• Diltiazem ointment: for Anal Fissures

Toxicity

• Worry about hyperK → High-dose IV Insulin + glucose