Predominant Symptom: Obliterative Vasculopathy (Scleroderma) , restricted to hand and face

• Ab: Anti-centromere

a.k.a. CREST

• C - Calcinosis Cutis
• R - Raynaud phenomenon
• E - Esophageal Dysmotility
  • GERD
  • Esophageal Dysphagia, Aspiration
  • Constipation
• S - Sclerodactyly + Puffy Faces
• T - Telangiectasia

*Can cause PH - Pulmonary hypertension without lung danage