An Adrenal Hyperandrogenism

Relevant Physiology

Etiology

• Autosomal recessive disorder
• Enzymatic deficiency of
  • 21 Hydroxylase (most common) - discussed below
  • 11 Hydroxylase
  • 3b Hydroxysteroid dehydrogenase

Pathogenesis

Adrenal Physiology

1. Low cortisol and/or aldosterone ↓
2. Random Cortisol Feedback → elevated ACTH ↑
3. Accumulation of 17-OH ↑ → convert to testosterone ↑

Classifications, Presentation, Management

CCAH

NCAH

Investigations

Tests

DDx + Things to rule out