Pathway	Related Disease		Targetting Drugs
Mesocortical (VTA → PFC)	‣ negative symptoms	D1 > D2
Mesolimbic (VTA → NAc)	‣ positive symptoms (‣)	D2	‣
Nigrostriatal (SN - BG striatum)	‣	D1 (direct pathway), D2 (indirect pathway)	‣
Tuberoinfundibular (hypothalamus)	‣, ‣, ‣	D2