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• known to cause collagen-related adverse effects
  • Rupturing of AAA - Abdominal Aortic Aneurysm or !AD - Aortic Dissection
• Known to cause C. difficile
• Generation I -> IV (decreased P.S coverage, increased anaerobe)
  • II: Ciprofloxacin (Gen II) : good GN, P.S coverage (need higher dose - 75 mg), Not good GP, Anaerobe
  • III: Levofloxacin (Gen III) (pneumonia - good lung penetration, cover Strep. P very well), decrease P.S coverage
  • IV: Moxifloxacin (Gen IV) ****(covers anaerobe - abdominal infection)