Immune Complex Mediated
| Type | Type III |
|---|---|
| Time frame (exogenous exposure) | 1-3 weeks (drug/serum) |
| Immune Reactant | Immune Complex (Ag-sAb) mediated |
| Antigen | Soluble |
| Effector forDamage Pathway | Complement, phagocyte Immune complex bine to basement membrane of blood vessel – Neutrophil attempt to phagocytose – degranulate – lysosomal enzyme + reactive O2 species – vasculitis – more DNA released (commonly @ where blood is being filtered)@ Kidney: glomerulonephritis @ Joint: arthritis |
| Examples | o Lupus (DNA and nucleoprotein) - C3, C4: track disease progression over timeo Serum sickness (anti-venom antibodies)o Urticarial vasculitis (not sure) |
| Note | vs type II: o Systemico rapid consumption of complement (C3, C4)o Tissue damage at places where blood is being filtered (where the immune complex is deposited, not made) |