| Dosing Type | Dosage | Pros/Cons | Trough level |
|---|---|---|---|
| Once Daily Dose | 5–7 mg/kg Q24h | higher peak (better bactericidal), lower trough (less renal toxicity ) | undetectable by 18–24 hours post-dose |
| Multiple daily dosing | 2–2.5 mg/kg Q8hrs | more steady, good for enterococcal infective endocarditis | 4–6 mg/L before 4th dose |