Hereditary nonpolyposis colorectal cancer

MMR

a.k.a. lynch syndrome

Prophylactic proctocolectomy if screening = positive

GI and GYN cancer: 3 most important

CRC - Colorectal cancer

Endometrial Cancer

• most common inherited cause of endometrial cancer, New Diagosis of Endometrial should consider screening (tissue all get tested) → referal to genetic counciling if high risk
  • Pathology IHC staining
  • Microsettelite instability

Ovarian cancer