Myelodysplastic Syndrome

• Risk of AML ****transformation
• Blast burden < 20% (vs. AML)
• Macrocytic anemia + hypogranulation of neutrophil
• Need ..?
• Not curable
• Treatment
  • Low risk, synthetic EPO stimulation, G-CSF
  • High risk, Chemo (<65), allogenic stem cell transplant (<75)

Presentation

Macrocytic Anemia (> 100) (Oval, Neutrophil Hyposegmantation on Peripheral Blood Film )

Pancytopenia ↓