Type I: NF1 gene - affect PNS in extremities & skin

Presentation

• cafe-au-lait spots @ back, buttocks, thighs

  

• cognitive impairments

• grow from nerve sheath, affect schewann, fibroblast, immune cells

• childhood onset

• Lisch nodules (in eye)

• Axillary freckling

• painless mobile lump under skin

CPsuedoOrthosus

Scoliosis