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Abuse

Opioid Use Disorder
!Opioid Intoxication
Opioid Withdrawal (3/9, min - dys) </aside>

Opioid Conversion

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2:5:10:60-100

Hydromorphone vs. Oxycodone vs. Morphine vs. Codine

*Reduce to 50-70% of previous dose when converting

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Opioid-Acetaminophen Combos

Special Population PK Changes

	Renal Failure	Liver Failure
‣	Preferred*	Preferred*
‣	Preferred*	AVOID
‣	Reduce Dose	Preferred*
‣	AVOID	AVOID

*(Dose reduce but) Preferred

Conditions + Dosing

Keep the patients < 90 mg daily of morphine equivalent (Upper limit)
Palliative Care Dosing

Guidelines

WHO Pain Ladder: Opioid Px Guideline

A/E

Short-term Effect