A relatively rare autoimmune disorder where vitamin B12 deficiency secondary to intrinsic factor (IF) deficiency → Megaloblastic Anemia

Relevant Physiology

Etiology

• autoimmune disorder: Autoimmune Disease
  • Anti-IF
  • Anti- parietal cell

Pathogenesis

• Ab attack → Atrophic gastritis → deficiency of IF and acid (parietal cell), pepsinogen (cheif cell)
  • IF deficiency → Megaloblastic Anemia