| Tradename |
Seroquel IR |
Seroquel XR |
| Dosage Strengths |
25 mg, 50 mg, 100 mg, 150 mg, 200 mg, 300 mg, 400 mg tablets |
50 mg, 150mg, 200mg, 300mg, 400mg tablets |
| Half-life |
Shorter |
Longer |
| Dosing |
BID dosing |
Once daily dosing |
| Starting Dose (Bipolar Mania) |
50 mg BID (increase by 100-200 mg/day) |
300 mg PO daily (can increase by 300 mg/day) |
| Target Dose (Bipolar Mania) |
400-800 mg PO daily[5] |
400-800 mg PO daily |
| Advantages |
May be more beneficial in acute mania and psychosis due to more sedating features |
Faster dose titration and less sedating.[6] |
| Disadvantages |
More sedating |
Lower side effect profile |