Relevant Physiology

Presentation

S/S, Physical Exam Finding

• Resp Pt
• Skin rashes (erythema nordosum, lupus pernio)
• Uvelitis
• !AFib - Atrial Fibrillation, cardiomyopathy
• Liver (transaminitis and/or fibrosis)
• CNS symptoms → rare but serious
• Renal AKI

Risk factors

• African
• FHx of sarcoidosis
• PMHx of
  • Mycobacterium tuberculosis
  • Lyme Disease

Investigation

Tests

• Blood Work: Hypercalcemia, increased ACE
• CXR - Chest X ray
  • Early stage (1,2) → Bilateral hilar Adenopathy
  • Late stage (3,4) → ILD and Fibrosis (upper lobe)
• PFT - Pulmonary Function Tests
  • Pattern of Bronchospasm and Restrictive PFT
  • Low DLCO (75% - 125%)