Summary

HAV	IgM, IgG
HBV	Anti-Core IgM, Anti-Core IgG, Anti-surface IgG, Antigen
HCV	HCV RNA, Anti-Core IgG, Cryoglobin

HBV

Outcome	Interpretation	Next Step
HBsAg+	Active Disease
Anti-HBc IgM+	Acute phase infection
Anti-HBc IgG+	Current/Past infection
Anti-HBs IgG+	Immunity derived from vaccine OR resolved past infection (in some cases can be undetectable after infection)

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E_Ag: don’t develop in acute phase infection
- E_Ag + = High replicative state
- E_Ag- & E_Ab+ = low replicative state
S_Ab: ONLY develop after infection or vaccine (you no longer have the infection)
Acute infection: Positive S_Ab, E_Ab, DNA, IgM

HCV

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Value	Interpretation	Next Step
‣ RNA (NAAT)	active infection
Anti-HCV Ab+	current or past infection
‣	hronic immune stimulation and B-cell lymphoproliferation driven by persistent viral antigen exposure.