Skin: Vitamin D3 → Chloecalciferol, Ergocalciferol

Liver: 25-OH Vitamin D → Alfacalcidol

Kidney: 1, 25-OH Vitamin D → Calcitriol (1,25 VD)

Screenshot 2024-03-31 at 11.13.04 PM.png

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Calcitriol (1,25 VD) vs. PTH : Effect on PO4 and Ca

Ca (2+) → Net Increase with PTH (normal cases)

Molecule PTH Calcitriol (1,25 VD)
Kidney ↑ Ca re-absorption ↑ Ca
Intestine NA ↑ Ca absorption
Bone ↑ Osteoclast, ↑ Ca ↑ Osteoclast, ↑ Ca

PO4 (3-) → Net decrease with PTH (normal cases)

Molecule PTH Calcitriol (1,25 VD)
Kidney ↓ PO4 (PTH dominant) ↑ PO4
Intestine NA ↑ PO4 absorption
Bone ↑ Osteoclast, ↑ PO4 ↑ Osteoclast, ↑ PO4
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Normal range