Glucagon-like peptide 1 (GLP-1) agonists, an Incretin

Examples: Liraglutide (Victoza), Semaglutide (Ozempic) , Exenatide (Byetta) , Dulaglutide (Trulicity)

Benefit (vs other glycemic control measure) :

• 1-2% A1C reduction → increase insulin sensitivity, glucose-dependent insulin release
  • Better than Sulphonylureas (”G…ide”) in risk of hypoglycaemia
• Weight Loose
• CV Protective effect, recently found renal protective effect

Contraindication

• Severe CKD
• MENS 2 (Type 2A) (Paraganglioma)
• Medullary Thyroid Carcinoma