• → not as localized
• Ischemia (NSTEMI, angina)
• Strain (hypertrophy → subendocardial hypoperfusion → Hypertrophic cardiomyopathy)

"STEMI-equivalents"

1. Global ST Depression and Elevation in aVR
   • can indicate severe left main or multi-vessel coronary artery disease.
2. Global ST Depression + hyperacute T wave (de Winter’s sign)
3. Dynamic T wave inversions/flattening (OMI)