Catechol-O-methyltransferase (COMT) Inhibitors
| Prevent dopamine breakdown in the brain → increased dopamine availability
Increase ‣ effect duration | Decrease “off” time and increase “on” time (address ‣ )
Enhance motor response in patients with motor fluctuations | • ‣ • Exaggerate S/E of levodopa • Urine may turn orange (benign issue)