[ di-JOX-in ]

Effect: Increase contractility, increase CO with decreased EDP, AV node inhibition (slow HR)

Conditions: Arrhythmia ECG

CI: AV Blocks ECG , !Renal Failure

MOA: unknown, possibly lower vagal tone

Side effects:

• AV Block
• Bradycardia
• Increased toxicity with
  • Renal dysfunction
  • PgP inhibitor

Reversal

• Antidigoxin Fab antibodies