GH

• Protein synthesis
• Build bones
• Promote Na, K. water retension

IGF-1

• Antagonize Insulin
• Stimulate lipolysis

In childhood, GH + IGH-1 → epiphyseal prechondrocyte differenciation

Required for normal growth in fetus and child → esp. CNS

• Healthy child growth requires GH, Cortisol, TH
• Cortisol and TH are required for normal GH secretion:GH Physiology