IgG Mediated, Delayed
**Some Drug Allergy (**e.g. heparin, abx)
Myathesia Gravis (nicotinic ach receptor)
Grave’s Disease (TSH receptor, ++)
Immune thrombocytopenic purpura (platelet)
Chronic urticaria and angioedema (IgE, free and on mast cells) – can look like Type I, but no exogenous allergen ID
| Type | Type II |
|---|---|
| Time frame (exogenous exposure) | 2-7 days (drug) |
| Immune Reactant | Ab (IgG) mediated |
| Antigen | Cell-/ Matrix- bound |
| Effector forDamage Pathway | Complement, phagocyte, FcR+ cells, NK cells, recptors themselves Local activation of complement pathway – Opsonization/MAC (cytotoxicity); obstruction/activation of receptor (dysfunction) |
| Note | vs type III: |