<aside> 💡 *In anyone with a uterus, Estrogen treatment must be combined with Progesterone-related drugs to avoid Uterine hyperplasia .

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Estrogen options:17B - Estradiol (Estrace®), CEE - (Premarin)®,

Progesterone options: Progesterone-related drugs → protection against endometrial cancer, alone mdoerately effective for VMS

Key Indications

Risk & Benefits

CI

• Requirement:

  • < 10 yr since the onset of menopause

  • low risk for Breast cancer

  • low risk for CVD - Atherosclerosis

    

    *Old guideline: < 5 yr of use

    

SUMMARY

• MHT is most appropriately initiated <60 years and/or within 10 years of menopause
• MHT should certainly be encouraged in women who have undergone natural/surgical menopause age 40; and most likely age 45