Conditions
- Alcohol Use Disorder
- Start naltrexone at 25 mg per day for 4 days, and then increase to 50 mg per day.
- Bilirubin and liver transaminases should be checked before initiating treatment, and again at 3 months.
- Opioid Use Disorder
Contraindications
- Opioid (Narcotics) use including:
- Anticipated need for opioid analgesics within the next 7 days
- Current illicit opioid use (as indicated by self-report or a positive urine screen)
- Buprenorphine-naolxone (Suboxone) or methadone maintenance therapy for the treatment of opioid dependence
- Currently undergoing opioid withdrawal[2]
- Safety in liver cirrhosis is not known, and thus naltrexone is contraindicated in acute hepatitis and liver failure. Do not start naltrexone if the patient's bilirubin is elevated or the transaminases are more than 3 times above normal limits.
- History of sensitivity to naltrexone, to structurally similar compounds (e.g. - naloxone or nalmefene), or to any inactive ingredients in the tablet
A/E: