https://www.youtube.com/watch?v=MeUXLr9tOfk

Extra-vascular Hemolysis

• Hemotylic Aplastic Anemia
  • “Lemon Yellow” appearance (Jaundice + Pallor )
• (+ Co-morbid G6PD Deficiency) → !Hemolysis Crisis
• (+ Parvo B19) = Bone Infarction → Aplastic Anemia
• Extra-medullary hematopoiesis → Chip Munck Faces
• Sickle Cell Nephropathy → Hematuria

Vaso-occlusive crisis

• Dactylitis (6-9 mon. < 2 yo)
• Acute Chest Syndrome (Adult)
• Auto-splenectomy (Functional Asplenia) (by 12 mon.)
• Recurrent Venous-insufficiency-like ulcer (at shine)
• PH - Pulmonary hypertension
• Chronic Abdominal Pain
• Proliferative Retinopathy
• !Stroke (CVA) in Children