Mineralocorticoid Receptor Antagonists (MRA)
MRA
K+ sparing diuretic with intrinsic anti-androgen property
Monitor K+ level closely
At high doses (1mg/kg/day) l
owers adrenal androgen production
and
partially blocks androgen receptor
Conditions:
↑High BP
Congestive HF
HF - Heart Failure
Acne
(Anti-androgen)
Hyperaldosteronism
↑
Hyperandrogenism