Pathogenesis

• Progressive growth, some time for collateral
• Lead to !CLI - Critical Limb Ischemia (6Ps, 6h) IF there is a concurrent reduction in CO
  • Systemic reduction in limb perfusion, contralateral pulse would be weak as well
  • Urgent Tm focus on the underlying disease

Presentation

Signs and Symptoms

• Thrombotic occlusion: asymptomatic
• May be claudication

4 Ethology and Tm

1. Atherosclerosis

• CVD - Atherosclerosis
  • Plaque Rupture → Acute thrombus formation

2. Hypercoagulative state

(mostly venous)

• DVT DVT
• HIIT
• Hypercoagulability
• Hyperviscosity
• low arterial flow

3. AD

• !AD - Aortic Dissection

4. Bypass Graft Occlusion

• CABG