Examples: atorvastatin , rosuvastatin

Conditions/Effect

• treat DLD - Dyslipidemia ↑
  • Risk factor for CAD
  • Risk factor for Diabetes Mellitus (T1DM, T2DM ) and its complications
• also stabilizes the plaque in CVD - Atherosclerosis

MOA: inhibit HMG Co-A reductase (cholesterol synthesis), increase LDL uptake from blood

• Treat hypercholesterolemia: Reduce LDL-C by ≥ 50%
• also stabilizes the plaque

Side effects:

• Myalgia, Arthritis
• Headache
• Inflammatory Myositis (rare)

CI: active Liver diseases