Types of Estrogen

• E1 - Estrone - Menopause
• E2 - Estrodiol - reproductive year
• E3 - Estriol - pregnancy

Function

1. Menstruation

   1. cervix mucus: egg-yolk like
   2. endometrium: proliferative
   3. pituitary: LH surge

2. Sexual development

   • Uterus
   • Breast (X breast development = low E2)
   • Public hair (mainly due to Adrenal Androgens)
   • Gynocoid body changes
     • Skin softening
     • Muscle fat distribution
     • Higher pitched voice
     • Bone shape (narrow shoulder, wide hip, diverging arm)

3. Other organs

   • Brain
   • Bone
   • Heart
   • Endocrine
     • Pro-longed estrogen insufficiency increases insulin resistance, leading to T2DM