Very Effective for Leukemia (AML, ALL) → 2 Step Remission-Induction Chemotherapy
https://www.youtube.com/watch?v=t7QDJOXeux4
| Phase | Drug Classes Acting Here |
|---|---|
| S phase | ‣ , Topoisomerase inhibitors |
| G2 phase | Bleomycin |
| M phase | Vinca alkaloids, ‣ |
| Cell-cycle nonspecific | ‣, Anthracyclines, ‣ |
Monitor for !TLS - Tumor lysis syndrome on first 2-3 days of initiation
| Drug/Class | Buzzword Toxicity |
|---|---|
| ‣ | ‣ |
| ‣ | ‣ |
| ‣ | Nephrotoxicity + ototoxicity |
| Vincristine | Peripheral neuropathy |
| ‣ | Hemorrhagic cystitis |
| ‣ | Mucositis |
| Irinotecan | Severe diarrhea |