• Total

    • Hyperbilirubinemia

  • Fractionated:

    • Elevation in Conjugated (Direct) DDx
      • Liver diseases
      • Cholestasis (biliary obstruction)
    • Elevation in Un-conjugated (Indirect) DDx
      • !Hemolysis, SCD - Sickle Cell Disease (Crsis)
      • Gilbert’s syndrome

  • Bilirubin conjugation pathway

  • In Liver diseases , the secretory function fails before the conjugation function

    • Increased Total and Conjugated Bilirubin

  • In !Hemolysis, there is excessive production of heme

    • Increased total and unconjugated Bilirubin