Def.

• Histological: Defined by the presence of fibrous septum
• Clinical: Defined by the presence of complications (Varices, Ascites, HE, HCC)

Relevant Physiology

• Liver Physiology

Etiology

• SLD/FLD- Steatotic/Fatty Liver Diseases
  • Alcohol (RF) → AFLD - Alcoholic Fatty Liver Disease
  • Metabolic Disorder, Diabetes Mellitus → MASLD/NAFLD
• Viral Hepatitis → Chronic inflammation
  • HBV
  • HCV
• Genetic Liver Disease
  • Wilson’s Disease,
  • Hemachromatosis
  • AATD - Alpha-1 Antitrypsin Deficiency (Lung+Liver)
• Autoimmune Liver Disease
  • PSC - Primary sclerosing cholangitis,
  • PBC - Primary Biliary Cirrhosis
• Budd–Chiari Syndrome
• RV failure

Pathogenesis

• Hepatitis
• Cholestasis

Staging

• Cirrhosis Stages

Presentation