• Cortical Collecting Duct
  • RAAS

    • Amiloride , directly inhibiting ENaC

    • Compared to MRA → down-regulating ENaC through gene expression (takes longer)

    • Aldosterone action site → Causes Na+ to be re-absorbed in exchange of K+

      Screenshot 2024-05-22 at 11.42.47 AM.png

      • ENaC
  • Remove K Potassium (3.5-5)
  • Remove Blood pH and produce HCO3 - Bicarbs
  • Remove nitrogenous waste (from glutamine) through Ammoniagenesis