• PCT producesNH3 - Ammonia
• CCD produces Blood pH
• Binds to make NH4+ - Ammonium
• Excreted by the urine

1: 1 Ratio:

• Production of HCO3 - Bicarbs, removal of Blood pH and
• Removal of glutamine (Urea Cycle)

Diseases

1. Process impaired by severe !Renal Failure, CKD →
   • eGFR (≥ 60mL/min) < 25%
2. RTA - Renal tubular acidosis