CI: RenalD, HyperK

Examples:

• Amiloride
• Triamterene

Effect: potassium-sparing diuretic, lowering BP

Conditions: Hyperaldosteronism ↑

CI:

• Kidney dysfunction:
  • CKD
  • Diabetic Nephropathy
  • !anuria
• !Hyperkalemia - ↑K (> 5) (> 5.5)

Side effects:

• !Hyperkalemia - ↑K (> 5)

MOA: block ENaC Na transport at Cortical CD , thereby inhibiting sodium-potassium exchange

Admin: 5-20 mg daily