Minimal change disease

Autoimmune condition (Nephrotic syndrome (>3.5)), injury to podocyte

• Damage to glomeruli → protein “leaks out”
  • Called minimal change - because can only see changes under electron microscope!
  • vs. primary FSGN :
    • Not visible under microscope
    • No scarring yet - respond well to Prednisone
• Common in children!
• Can be primary or secondary
  • Common secondary causes - Hodgkin Lymphoma (HL) , NSAID , COX2i (Celecoxib, Rofecoxib)
  • Treatment → Steroids (primary), treat cause (secondary)