<aside> 💡

Acetaminophen is NOT an NSAID

• Acetaminophen/Tylenol: blocks pain signal, not the inflammatory side of things
• NSAIDs are helpful for short-term pain relief, helps in the buffer zone before more definitive therapy starts working </aside>

<aside> 💡

Cautious in Older Adult > 65 (RF)

• esp. with chronic conditions affected by the above side effects </aside>

MOA:

• COX-inhibitor → inhibit PG production (pro-inflammatory)

Conditions:

Anti-inflammatory

• OA - Osteoarthritis
• 1st line in Ankylosing Spondylitis
• Acute Inflammatory Pain Management
  • Crystalline Arthritis
  • RA - Rheumatoid Arthritis (before DMARD kicks in)

Analgesic

• Headache
• Dysmenorrhea

Contraindications

Kidney Insult CKD

Bleeding Risk • Hx of GIB - GI Bleeding, !Perforated Gastric ulcer, Acute PUD - Peptic Ulcer Disease.Thrombocytopenia ↓, Cirrhosis

BP Effect • !CHF (H+W) (Na retention bad) • Uncontrolled ↑High BP , etc.

Side effects: