| Atypical agents | Anticholinergic | Drowsiness | Insomnia/ agitation | Orthostatic hypotension | QTc prolongation* | Gastrointestinal toxicity | Weight gain | Sexual dysfunction | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | Agomelatine§ (not available in United States) | 0 | 1+ | 1+ | 0 | 0 | 1+ | 0 | 0 to 1+ | | ‣ | 0 | 0 | 2+ | 0 | 0 to 1+¥ | 1+ | 0 | 0 | | Dextromethorphan-bupropion | 0 | 1+ | 1+ | 0 | 0 to 1+¥ | 1+ | 0 | 1+ | | Mirtazapine | 1+ | 4+ | 0 | 0 | 1+ | 0 | 4+ | 1+ |