OP Def.

• BMD (≥ -2.5) ≤ - 2.5 (clinical osteoporosis)

Bad VF Def.

• One of the two
  • severe, recent Vertebral Fracture (> 40%, within 2 yr)
  • multiple Vertebral Fracture

Options

• Terparatide, CI: ↑PTH, ↑Ca, → switch to Anti-resorptive in 2 yrs
• Romosomab, CI: ↓Ca, MI, Stroke → switch to Anti-resorptive in 1 yrs