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Examples: Canagliflozin , Empagliflozin (Jardiance®) , Dapagliflozin

Effect:

• A1C reduction 0.7-1% → block glucose reabsorption in kidney
• Weight loose
• CV protective
• Renal protective

Conditions

• T2DM , ↑ Hyperglycemia (> 7)
• HFrEF (HF w/ reduced EF)
• HFpEF (HF w/ preserved EF)
• Diabetic Nephropathy
• CKD