<aside> 💡 Key Points

PD: Hematuria (non-glomerular disease can also present as GN), +/- Nephritic syndrome
Affect eGFR (≥ 60mL/min)
UM: RBC Cast
Biopsy: Proliferative (Pathology Report)
Emergency: Can progress to End-stage !Renal Failure within days or weeks </aside>

Etiology

See Nephritic syndrome DDx
- *Glomerulonephritis is the disease (biopsy/pathology).
- Nephritic syndrome is the clinical expression of that disease

C3	C4	Diseases	Pathophysiology	Additional Test
↓	normal	Post-infection (HCV, GAS, IE)	Alternative Pathway	‣ (HCV)
‣ (GAS)
IE workup
normal	↓	‣	ummm	Kidney biopsy
↓	↓	‣	Classic Pathway	Lupus work-up
normal	normal	‣
‣
‣ (driven by neutrophil)

| Not about complements | Anti-ANCA, Anti-IgA, Anti-GBM |

Treatment

High-dose Oral Corticosteroid (OCS) and Immunosuppression drugs